The study focuses on three different risks that are affected through climate-related water challenges: (1) livelihoods and food security, (2) political stability and violence, and (3) interstate conflict and cooperation. Drawing on a review of existing literature and publicly available data, expert interviews, and scenario-building workshops, it identifies social, economic, institutional, and political factors that will shape the future vulnerability and resilience to the effects of global warming. Based on an assessment of current interventions, it derives recommendations for adaptation measures that the riparian countries and regional institutions can implement to mitigate future risks and to seize opportunities for increased cooperation and resilience building.